| Date | Home | Away | Location |
| 8/21/21 | Rams | Patriots | Strack Intermediate |
| 8/21/21 | Grizzlies | Redcats | Grand Oaks High School |
| 8/21/21 | Texans | Eagles (Broncos Sophomore) | Klein Collins High School |
| 8/21/21 | Oilers | Bengals | Klein Oak High School |
| | | | |
| 8/28/21 | Eagles (Redcats Sophomore) | Rams | Klein Collins High School |
| 8/28/21 | Bengals | Broncos | Krimmel Intermediate |
| 8/28/21 | Oilers | Patriots | Klein Oak |
| 8/28/21 | Grizzlies | Texans | Grand Oaks High School |
| | | | |
| 9/11/21 | Texans | Patriots | Klein Cain High School |
| 9/11/21 | Broncos | Oilers | Ulrich Intermediate |
| 9/11/21 | Bengals | Rams | Krimmel Intermediate |
| 9/11/21 | Eagles (No Sophomore Game) | Redcats (No Sophomore Game) | Klein Collins High School |
| | | | |
| 9/18/21 | Patriots | Redcats | Tomball High School (Mayor's Cup) |
| 9/18/21 | Grizzlies | Eagles (Oilers Sophomore) | Grand Oaks High School |
| 9/18/21 | Rams | Broncos | Strack Intermediate |
| 9/18/21 | Bengals | Texans | Krimmel Intermediate |
| | | | |
| 9/25/21 | Redcats | Broncos | Tomball Junior High School |
| 9/25/21 | Eagles (No Sophomore Game) | Patriots (No Sophomore Game) | Klein Collins High School |
| 9/25/21 | Bengals | Grizzlies | Krimmel Intermediate |
| 9/25/21 | Texans | Oilers | Klein Cain High School |
| | | | |
| 10/2/21 | Broncos | Grizzlies | Ulrich Intermediate |
| 10/2/21 | Rams | Texans | Strack Intermediate |
| 10/2/21 | Redcats | Oilers | Tomball Junior High |
| 10/2/21 | Eagles (Patriots Sophomore) | Bengals | Klein Collins High School |
| | | | |
| 10/9/21 | Oilers (No Sophomore Game) | Eagles (No Sophomore Game) | Klein Oak High School |
| 10/9/21 | Texans | Redcats | Klein Cain High School |
| 10/9/21 | Rams | Grizzlies | Strack Intermediate |
| 10/9/21 | Patriots | Broncos | Willow Wood Junior High School |
| | | | |
| 10/16/21 | Redcats | Bengals | Tomball Junior High School |
| 10/16/21 | Oilers | Rams | Klein Oak High School |
| 10/16/21 | Broncos | Texans | Ulrich Intermediate |
| 10/16/21 | Patriots | Grizzlies | Willow Wood Junior High |
| | | | |
| 10/23/21 | Broncos (No Sophomore Game | Eagles (No Sophomore Game) | Ulrich Intermediate |
| 10/23/21 | Patriots | Bengals | Willow Wood Junior High |
| 10/23/21 | Grizzlies | Oilers | Grand Oaks High School |
| 10/23/21 | Redcats | Rams | Tomball Junior High School |
| | | | |
| | | | |
PLAYOFFS BEGIN 10/30/21
OPPONENTS AND LOCATIONS ARE BASED ON SEEDINGS.
SEEDINGS DO NOT CHANGE THROUGHOUT PLAYOFFS.